EFFICACY AND TOLERABILITY OF BRODIMOPRIM AND ROXITHROMYCIN IN ACUTE SINUSITIS OF BACTERIAL ORIGIN IN ADULTS

In two ear, nose and throat (ENT) divisions, 74 patients affected by a cute sinusitis of bacterial origin were selected and, after randomizat ion in two balanced groups following an open parallel group design, as signed to treatment with brodimoprim and roxithromycin. At the beginni ng, after 3 days, 7 days and at the end of treatment the following sym ptoms were evaluated, using a four-step score: intensity of facial pai n, headache, nasal stiffness, hyposmia, nasal secretion. The mean trea tment period was 8.7 days. Tolerability was evaluated through registra tion and analysis of side effects and laboratory blood tests. The comp arison between groups showed a better activity of brodimoprim on facia l pain, headache, nasal stiffness and nasal secretion, The presence of resistant bacterial strains was greater in the group treated with rox ithromycin (30.8%) when compared with the brodimoprim group (12.5%). S ide effects were reported in 5 patients treated with brodimoprim and i n 3 patients in the control group. Lab tests did not show serious vari ations.