SYNTHETIC STUDIES ON ANTIBIOTIC DYNEMICIN-A - SYNTHESIS OF CYCLIC ENEDIYNE MODEL-COMPOUND OF DYNEMICIN-A

Authors
NISHIKAWA T INO A ISOBE M
Citation
T. Nishikawa et al., SYNTHETIC STUDIES ON ANTIBIOTIC DYNEMICIN-A - SYNTHESIS OF CYCLIC ENEDIYNE MODEL-COMPOUND OF DYNEMICIN-A, Tetrahedron, 50(5), 1994, pp. 1449-1468
Citations number
59
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
5
Year of publication
1994
Pages
1449 - 1468
Database
ISI
SICI code
0040-4020(1994)50:5<1449:SSOAD->2.0.ZU;2-0
Abstract
Dynemicin A, a potent antitumor antibiotic has novel 10-membered cycli c enediyne moiety. The bicyclo[7.3.1]-tridecadiyne system having anili ne moiety of this antibiotic was designed and synthesized from lepidin e in 10 steps. The synthesized compound can be cycloaromatized to Berg man product via pinacol rearrangement under acidic condition, and also exhibited DNA cleaving activity.