T. Nishikawa et al., SYNTHETIC STUDIES ON ANTIBIOTIC DYNEMICIN-A - SYNTHESIS OF CYCLIC ENEDIYNE MODEL-COMPOUND OF DYNEMICIN-A, Tetrahedron, 50(5), 1994, pp. 1449-1468
Dynemicin A, a potent antitumor antibiotic has novel 10-membered cycli
c enediyne moiety. The bicyclo[7.3.1]-tridecadiyne system having anili
ne moiety of this antibiotic was designed and synthesized from lepidin
e in 10 steps. The synthesized compound can be cycloaromatized to Berg
man product via pinacol rearrangement under acidic condition, and also
exhibited DNA cleaving activity.