The academic physician-investigator faces many challenges. Obtaining f
unding to support research is the greatest impediment. The National In
stitutes of Health, the single largest source of grants for the academ
ic physician-investigator, approved only 14.2% of new investigator gra
nt applications in 1990, compared with 40% in 1965 and 1975. Physician
s submitted 25% of all applications, and they have priority scores sim
ilar to those applications submitted by investigators with PhD degrees
. The 14.2% funding rate for new investigator-initiated grants is cons
iderably less than the 56% success rate of amended renewal investigato
r-initiated grants. These trends in funding can be discouraging to the
new physician-investigator. In addition, more emphasis is placed on c
linical practice to generate money to support the new academic physici
an. These two facts, reduced probability of obtaining a grant and the
perceived need to see more patients for salary support, may jeopardize
retention of young faculty members. Moreover, training to prepare phy
sicians for academic careers has been poor, with no attention given to
the projected needs of the academic centers or the nation. This artic
le describes the dilemma facing young physician-investigators and prov
ides recommendations for improvement to the leaders of American medici
ne.