A LEUCINE ZIPPER-LIKE MOTIF AND A BASIC REGION-LEUCINE ZIPPER-LIKE ELEMENT IN RAT RIBOSOMAL-PROTEIN L13A - IDENTIFICATION OF THE TUM(-) TRANSPLANTATION ANTIGEN P198
Yl. Chan et al., A LEUCINE ZIPPER-LIKE MOTIF AND A BASIC REGION-LEUCINE ZIPPER-LIKE ELEMENT IN RAT RIBOSOMAL-PROTEIN L13A - IDENTIFICATION OF THE TUM(-) TRANSPLANTATION ANTIGEN P198, The Journal of biological chemistry, 269(8), 1994, pp. 5589-5594
The amino acid sequence of the rat 60 S ribosomal subunit protein L13a
was deduced from the sequence of nucleotides in two recombinant cDNAs
. Mature ribosomal protein L13a has 202 amino acids (the NH2-terminal
methionine is removed after translation of the mRNA) and a M(r) of 23,
330. Hybridization of the L13a cDNA to digests of nuclear DNA suggests
that there are 9-11 copies of the L13a gene. The mRNA for the protein
is similar to 800 nucleotides in length. Rat L13a is related to the S
accharomyces cerevisiae ribosomal proteins that have been provisionall
y designated rp22 and rp23 and to the eubacterial and archaebacterial
family of L13 ribosomal proteins. The mouse tum(-) transplantation ant
igen P198 is a mutant of the mouse homolog of rat ribosomal protein L1
3a. Rat ribosomal protein L7 has, at its NH2 terminus, five tandem rep
eats of a similar sequence of 12 amino acids (Lin, A., Chan, Y. L., Mc
Nally, J., Peleg, D., Meyuhas, O., and Wool, I. G. (1987) J. Biol. Che
m. 262, 12665-12671); L13a has, in its carboxyl-terminal region, amino
acid sequences with significant identity to L7 repeats 1, 3, and 5. L
13a also has a number of short amino acid sequences that are repeated,
a leucine zipper-like moth at its NH2 terminus, and a potential basic
region-leucine zipper element in its carboxyl-terminal region.