TC-99M-LABELING AND BIODISTRIBUTION STUDIES OF SOME DIHYDRO-1,4-THIAZINE AND 1,3-THIAZOLIDINE-CARBOXYLIC ACID-DERIVATIVES

Citation
J. Kornyei et al., TC-99M-LABELING AND BIODISTRIBUTION STUDIES OF SOME DIHYDRO-1,4-THIAZINE AND 1,3-THIAZOLIDINE-CARBOXYLIC ACID-DERIVATIVES, Journal of radioanalytical and nuclear chemistry, 186(1), 1994, pp. 75-87
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Analytical","Nuclear Sciences & Tecnology
ISSN journal
02365731
Volume
186
Issue
1
Year of publication
1994
Pages
75 - 87
Database
ISI
SICI code
0236-5731(1994)186:1<75:TABSOS>2.0.ZU;2-3
Abstract
Cephalosporanic acids (CEPHAs) such as dihydro-1,4-thiazine derivative s and 2-hydroxyalkyl-1,3-thiazolidine-4-carboxyllc-acid (HOTCAs) are b oth important biologically active molecules and complexing agents for several metals such as Fe, Zn, Pb, etc. The simplest way for the study of the effect of complex formation upon the biochemistry of these com pounds requires radiolabeled complexes. As Te-99m radioisotope gives t he best opportunity for imaging the in vivo process, Tc-99m-CEPHAs and HOTCAs were prepared and investigated. It was found that biologically active molecules like CEPHAs and HOTCAs can be labeled with Te-99m wi th good radiochemical yields. In case of one CEPHA compound, low but d efinite myocardial uptake was observed, while 3 of the HOTCAs showed c haracteristic renal uptake and wash-out without visualization of any o ther organs than the urinary tract.