A patient with mycosis fungoides that had progressed to tumor stage re
sponded to chemotherapy and electron beam treatment, but 6 years later
a peripheral neuropathy, extensive plaques, erythroderma, and enlarge
d pinnae containing acid-fast organisms developed while he was being t
reated with photopheresis. The skin lesions cleared with administratio
n of rifampin and dapsone, but a reversal reaction biopsy specimen sho
wed features of both mycosis fungoides and leprosy. This case raises t
he question of whether there may be an association between mycosis fun
goides and leprosy.