A 25-year-old black woman had a deformed right great toe. X-ray examin
ation revealed extensive lytic change in the distal phalanx, to which
technetium uptake was limited. The amputation specimen revealed a beni
gn chondroid syringoma in the subungual tissue that penetrated and per
meated the bone. Chondroid syringoma is rare in the foot, and we prese
nt what we believe is the first such immunohistochemically confirmed c
ase involving bone.