ACUTE MYELOID-LEUKEMIA IN A PATIENT WITH SECKEL SYNDROME

Citation
A. Hayani et al., ACUTE MYELOID-LEUKEMIA IN A PATIENT WITH SECKEL SYNDROME, Journal of Medical Genetics, 31(2), 1994, pp. 148-149
Citations number
7
Categorie Soggetti
Genetics & Heredity
Journal title
ISSN journal
00222593
Volume
31
Issue
2
Year of publication
1994
Pages
148 - 149
Database
ISI
SICI code
0022-2593(1994)31:2<148:AMIAPW>2.0.ZU;2-M
Abstract
We report a female patient with Seckel syndrome who developed acute my eloid leukaemia at the age of 26 years. Analysis of bone marrow chromo somes showed an abnormal clone with abnormalities involving multiple c hromosomes, including monosomy 7, trisomy 8, trisomy 11, and loss of t he long arm of chromosome 5. After treatment with chemotherapy, the pa tient experienced severe toxicity with profound bone marrow aplasia an d died of pneumonia two months later. We suggest that patients with Se ckel syndrome may be at risk of developing myelodysplasia and acute my eloid leukaemia. They may also have poor tolerance to cytotoxic therap y.