QUALITY OF ULCER HEALING - EVIDENCE FOR IMPAIRED RESTORATION OF SENSORY NERVES CONTAINING CALCITONIN-GENE-RELATED PEPTIDE IN THE SCAR OF ANEXPERIMENTAL GASTRIC-ULCER

Citation
A. Tarnawski et al., QUALITY OF ULCER HEALING - EVIDENCE FOR IMPAIRED RESTORATION OF SENSORY NERVES CONTAINING CALCITONIN-GENE-RELATED PEPTIDE IN THE SCAR OF ANEXPERIMENTAL GASTRIC-ULCER, European journal of gastroenterology & hepatology, 5, 1993, pp. 190000081-190000085
Citations number
NO
Categorie Soggetti
Gastroenterology & Hepatology
ISSN journal
0954691X
Volume
5
Year of publication
1993
Supplement
3
Pages
190000081 - 190000085
Database
ISI
SICI code
0954-691X(1993)5:<190000081:QOUH-E>2.0.ZU;2-T
Abstract
Background: Recent experimental and clinical data indicate that the su bepithelial gastric mucosa of a grossly healed ulcer remains histologi cally and ultrastructurally abnormal. The aims of this work were to (1 ) discuss new concepts on the quality of ulcer healing and (2) determi ne whether sensory nerves containing calcitonin gene-related peptide ( CGRP) are restored within the submucosal and mucosal scars of grossly healed experimental gastric ulcers in rats. Methods: In Sprague-Dawley male rats, gastric ulcers were produced by a topical serosal applicat ion of acetic acid. One to 2 months later specimens of gastric wall fr om grossly healed ulcers were obtained and immunostained for CGRP-cont aining sensory nerves. Results: In normal gastric mucosa, CGRP immunor eactivity was observed in nerve fibers of (1) the muscularis propria, (2) the submucosa in proximity to large vessels, (3) the basal mucosa and (4) the lamina propria adjacent to the microvessels. In gastric mu cosal and submucosal areas of grossly healed ulcers CGRP-containing se nsory nerve fibers were virtually absent. Conclusions: In addition to other histologic and ultrastructural abnormalities identified previous ly, in this study we demonstrated that scars of grossly healed experim ental gastric ulcers lack CGRP-containing sensory nerves.