INDUCTION OF NEW BONE BY ALLOGENEIC DEMINERALIZED BONE-MATRIX COMBINED TO BIOACTIVE GLASS COMPOSITE IN THE RAT

Allogeneic diaphyseal demineralized bone matrix (DBM) cylinders contai ning bioactive glass rods were implanted for 4 and 8 weeks in the abdo minal muscle wall of rats. DBM without glass served as control. The re sults suggest that new bone induction by DBM was accelerated by the pr esence of bioactive glass implants. However, the bone formation induce d by DBM on the glass surface was relatively small. The biocompatibili ty of the glass was verified by the absence of adverse cellular reacti ons in the interface region between glass and bone. The method used pr ovides a simple and fast means of exploring the characteristics of pot ential bone substitutes.