DETERMINATION OF RESIDUAL ETHYLENE-OXIDE BY 2 GAS-CHROMATOGRAPHIC METHODS

This work compares at a statistical level two different chromatographi c methods, a direct gas chromatography and a headspace gas chromatogra phy, each with its own standardisation. In the first method, the stand ardisation is performed with aqueous solutions of pure ethylene oxide. In the second method, the standardisation proceeds from the in situ s ynthesis of ethylene oxide by 2-chloroethanol, prior to the injection in the column. Furthermore, syringes and transfusion sets have been ex posed to pure ethylene oxide (EO) and, after desorption, residual EO h as been measured using both methods. Results are discussed using a sta tistical approach.