A MECHANISM-BASED CLEAVAGE OF LACTAM-CARBAMATES

Authors
WEI ZY KNAUS EE
Citation
Zy. Wei et Ee. Knaus, A MECHANISM-BASED CLEAVAGE OF LACTAM-CARBAMATES, Tetrahedron letters, 35(6), 1994, pp. 847-848
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
6
Year of publication
1994
Pages
847 - 848
Database
ISI
SICI code
0040-4039(1994)35:6<847:AMCOL>2.0.ZU;2-8
Abstract
Magnesium methoxide is a simple, effective and highly selective reagen t for the deprotection of N-alkoxycarbonyl lactams. The cleavage occur s via six-membered ring transition states involving coordination of ma gnesium ion with the oxygens of the carbamate and lactam carbonyl grou ps.