DESIGN AND SYNTHESIS OF A CIS-GLY-PRO, TYPE-VI TURN, DIPEPTIDE MIMETIC AND ITS USE IN FMOC-SOLID PHASE PEPTIDE-SYNTHESIS

Authors
GRAMBERG D ROBINSON JA
Citation
D. Gramberg et Ja. Robinson, DESIGN AND SYNTHESIS OF A CIS-GLY-PRO, TYPE-VI TURN, DIPEPTIDE MIMETIC AND ITS USE IN FMOC-SOLID PHASE PEPTIDE-SYNTHESIS, Tetrahedron letters, 35(6), 1994, pp. 861-864
Citations number
45
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
6
Year of publication
1994
Pages
861 - 864
Database
ISI
SICI code
0040-4039(1994)35:6<861:DASOAC>2.0.ZU;2-5
Abstract
The Fmoc-protected bicyclic molecules 7 and 8 have been produced as ci s-Gly-Pro peptide mimetics in nine synthetic steps starting from optic ally pure (R)-2-allylproline. Their use in solid-phase peptide synthes is has been demonstrated by their incorporation into analogues of cis- Gly(6)-Pro(7)-bradykinin.