RELATIONSHIP BETWEEN EXERCISE TOLERANCE, HEMODYNAMICS AT REST AND DURING EXERCISE AND EJECTION FRACTION, AND THEIR PROGNOSTIC RELEVANCE IN ASYMPTOMATIC POSTINFARCTION PATIENTS
K. Meyer et al., RELATIONSHIP BETWEEN EXERCISE TOLERANCE, HEMODYNAMICS AT REST AND DURING EXERCISE AND EJECTION FRACTION, AND THEIR PROGNOSTIC RELEVANCE IN ASYMPTOMATIC POSTINFARCTION PATIENTS, Cardiology, 84(1), 1994, pp. 33-41
In 309 postmyocardial infarction patients (age 40 +/- 7.7 years) witho
ut persistent ischemia there is only a weak correlation between ejecti
on fraction (EF) and exercise tolerance (r = 0.45, p < 0.01), and betw
een EF and maximum cardiac output (CO; 0.41, p < 0.01) and maximum pul
monary capillary wedge pressure (PCWP; r = -0.32, p < 0.001). The same
was true for exercise tolerance and maximum PCWP (r = -0.53, p < 0.00
1). A big scattering of individual values could be observed. Although
we found a high positive correlation between maximum CO and exercise t
olerance (r = 0.80, p < 0.001), in individual cases a low CO could be
related to high exercise tolerance and vice versa. In the multivariate
analysis, only the heart volume/kg body weight and maximum PCWP could
be shown to be of independent prognostic importance for survival and/
or mortality in the following years (chi(2) = 5.9, p < 0.015 and chi(2
) = 7.2, p < 0.007, respectively).