INTRACELLULAR AND EXTRACELLULAR HEMAGGLUTININS FROM DERMATOPHYTE TRICHOPHYTON-RUBRUM - DEVELOPMENT-SPECIFIC PRODUCTION AND NUTRITIONAL INFLUENCE

Trichophyton rubrum dermatophyte produces both intra- and extracellula r hemagglutinins during development in Sabouraud's media containing 4% D-glucose an 1% peptone. A time-course study has been designed for th e fungal growth with concomitant production of hemagglutinins. The eff ect of nutrients on the production of both hemagglutinins has been inv estigated using different media composition with varied D-glucose and peptone concentrations. The results show that highest amount of hemagg lutinin has been produced in presence of low D-glucose. Both intra- an d extracellular hemaglutinins agglutinate, besides several vertebrate erythrocytes, human erythrocytes of A, B and O blood group almost equa lly and thus are considered to be blood-group nonspecific.