POSITIVITY OF PATCH TESTS IN CUTANEOUS REACTION TO DICLOFENAC - 2 CASE-REPORTS

Authors
ROMANO A PIETRANTONIO F DIFONSO M GARCOVICH A CHIARELLI C VENUTI A BARONE C
Citation
A. Romano et al., POSITIVITY OF PATCH TESTS IN CUTANEOUS REACTION TO DICLOFENAC - 2 CASE-REPORTS, Allergy, 49(1), 1994, pp. 57-59
Citations number
14
Categorie Soggetti
Allergy
Journal title
Allergy → ACNP
ISSN journal
01054538
Volume
49
Issue
1
Year of publication
1994
Pages
57 - 59
Database
ISI
SICI code
0105-4538(1994)49:1<57:POPTIC>2.0.ZU;2-J
Abstract
Immune-mediated reactions to NSAIDs are unusual. We have observed two cases of maculopapular eruptions occurring 48-72 h after administratio n of diclofenac sodium. Patch tests performed with diclofenac were pos itive. The histopathologic findings resembled those of contact dermati tis with different degrees of dermal involvement. Clinical, allergolog ic, and histopathologic patterns strongly suggest a type IV mechanism of hypersensitivity. Patch tests play an important role in the assessm ent of possible immunologic mechanisms underlying cutaneous reactions to drugs.