REARRANGED NEOCLERODANE DITERPENOIDS FROM TEUCRIUM-BREVIFOLIUM

Authors
RODRIGUEZ B DELATORRE MC BRUNO M FAZIO C PIOZZI F SAVONA G PERALES A ARNOLD NA
Citation
B. Rodriguez et al., REARRANGED NEOCLERODANE DITERPENOIDS FROM TEUCRIUM-BREVIFOLIUM, Tetrahedron, 50(7), 1994, pp. 2289-2296
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
7
Year of publication
1994
Pages
2289 - 2296
Database
ISI
SICI code
0040-4020(1994)50:7<2289:RNDFT>2.0.ZU;2-F
Abstract
Two new diterpenoids, teubrevins A and B, have been isolated from the aerial parts of Teucrium brevifolium (Labiatae). The structures of teu brevin A [(1R,12S)-3 beta-acetoxy-4 alpha,18;15,16-diepoxy-6 beta-hydr oxy- 10-oxo-5,10-seco-1,6-cyclo-neo-cleroda-5(19),1 1] and its gp-hydr oxy derivative (teubrevin B, 2) were established by spectroscopic mean s, including an X-ray diffraction analysis of the former. Compounds I and 2 possess a new 5,10-seco-1,6-cyclo-neo-clerodane skeleton, the bi ogenesis of which is briefly discussed.