EFFECT OF SUPPLEMENTS WITH BIFIDOBACTERIUM-LONGUM AND LACTOBACILLUS-ACIDOPHILUS ON THE INTESTINAL MICROBIOTA DURING ADMINISTRATION OF CLINDAMYCIN

Thirty healthy volunteers in three groups participated in a study of t he influence of supplements containing Bifidobacterium longum and Lact obacillus acidophilus on the intestinal microbiota during administrati on of clindamycin. All groups received clindamycin perorally q.d.s. fo r 7 d. Group I also received a supplement with B. longum and L. acidop hilus, group IT received a supplement with B. longum and group III rec eived a placebo, for 21 d. The numbers of anaerobic microorganisms dec reased in all groups, but the reduction of bacteroides was significant ly smaller in group I than in group III (P<0.05). No subject in group III had any intestinal bifidobacteria on day 7. Significant decreases of volatile fatty acids in faecal specimens were seen (P < 0.05). Ther e was a smaller incidence of gastrointestinal discomfort in group I th an in group III(P<0.05).