Oa. Amire, THE FORMATION DYNAMICS OF CHOLESTEROL FILMS PREPARED BY SPONTANEOUS SELF-ASSEMBLY METHOD, Bulletin of the Chemical Society of Japan, 67(1), 1994, pp. 7-12
The dynamics of the process of formation of cholesterol films on a sol
id substrate prepared by the spontaneous self-assembly technique has b
een investigated. An expression for the coverage in a multilayer syste
m was derived. Application of the equation to cholesterol multilayer h
im formation kinetics shows that the approach to equilibrium of the se
lf-assembly process obeys first-order rate law. An observed adsorption
free energy change of -21..7 +/- 0.1 kJ mol(-1) was obtained for chol
esterol on quartz slide and a mean lifetime of cholesterol on the slid
e surface during deposition of 78 +/- 3 ks at 298.16 K. A mean lifetim
e for stearic acid adsorbed from hexadecane onto native aluminium oxid
e surface (data from elsewhere) was found to be 12.4 +/- 0.3 ks. The r
esults suggest dynamic processes which strongly depend on the formatio
n constant of the amphiphile for coordination to the substrate.