SALMETEROL INHIBITS ANAPHYLACTIC HISTAMINE-RELEASE FROM GUINEA-PIG ISOLATED MAST-CELLS

Authors
GENTILINI G DIBELLO MG RASPANTI S BINDI D MUGNAI S ZILLETTI L
Citation
G. Gentilini et al., SALMETEROL INHIBITS ANAPHYLACTIC HISTAMINE-RELEASE FROM GUINEA-PIG ISOLATED MAST-CELLS, Journal of Pharmacy and Pharmacology, 46(1), 1994, pp. 76-77
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of Pharmacy and Pharmacology → ACNP
ISSN journal
00223573
Volume
46
Issue
1
Year of publication
1994
Pages
76 - 77
Database
ISI
SICI code
0022-3573(1994)46:1<76:SIAHFG>2.0.ZU;2-G
Abstract
Salmeterol (1 nM-100 mu M) showed an inhibitory action on anaphylactic histamine release from mast cells, isolated from pleural and peritone al cavities of actively sensitized guinea-pigs and stimulated by incub ation with allergen. The effect is concentration-dependent and is redu ced by the beta-adrenoceptor antagonist propranolol (1 mu M). This stu dy supports the hypothesis of an antiinflammatory property of salmeter ol, which concerns cells involved in the early phases of asthma.