MHC CLASS-II ANTIGEN-PROCESSING - BIOLOGY OF INVARIANT CHAIN

Authors
SANT AJ MILLER J
Citation
Aj. Sant et J. Miller, MHC CLASS-II ANTIGEN-PROCESSING - BIOLOGY OF INVARIANT CHAIN, Current opinion in immunology, 6(1), 1994, pp. 57-63
Citations number
64
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
6
Issue
1
Year of publication
1994
Pages
57 - 63
Database
ISI
SICI code
0952-7915(1994)6:1<57:MCA-BO>2.0.ZU;2-4
Abstract
The invariant chain (li) has been shown to play a critical role in the assembly, intracellular transport and function of MHC class II molecu les. Recent studies suggest that these distinct activities can in many cases be attributed to distinct isoforms of li or to specific regions within it. Thus, regulation of li synthesis, post-transcriptional eve nts, and post-translational modification has the potential to dramatic ally modulate immune responses.