QUANTITATION OF FOLLICULAR NON-HODGKINS-LYMPHOMA CELLS CARRYING T(14 18) IN A PATIENT BEFORE AND AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION

Authors
MEIJERINK JPP GOVERDE GJ SMETSERS TFCM RAEMAEKERS JMM BOGMAN MJJT DEWITTE T MENSINK EJBM
Citation
Jpp. Meijerink et al., QUANTITATION OF FOLLICULAR NON-HODGKINS-LYMPHOMA CELLS CARRYING T(14 18) IN A PATIENT BEFORE AND AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION, Annals of oncology, 5, 1994, pp. 190000043-190000045
Citations number
13
Categorie Soggetti
Oncology
Journal title
Annals of oncology → ACNP
ISSN journal
09237534
Volume
5
Year of publication
1994
Supplement
1
Pages
190000043 - 190000045
Database
ISI
SICI code
0923-7534(1994)5:<190000043:QOFNCC>2.0.ZU;2-J
Abstract
Background: A competitive PCR method was developed, enabling accurate quantitation of residual lymphoma cells carrying the t(14; 18) in bloo d and bone marrow samples of follicular non-Hodgkin's lymphoma (NHL) p atients during treatment. Patients and methods: A patient with residua l lymphoma cells received an allogeneic bone marrow transplantation (B MT). Since BMT, the patient has been in continuing clinical complete r emission. Results: Using the competitive PCR and two-step PCR method, we were able to demonstrate a gradual decline in the number of lymphom a cells within consecutive patient blood and bone marrow samples after BMT. Conclusions: The competitive PCR is a suitable method for the de tection of minimal residual disease. Further research might reveal the clinical relevance of data obtained by this method.