FIRST ESTABLISHED PREGNANCY AND BIRTH AFTER INDUCTION OF OVULATION WITH RECOMBINANT HUMAN FOLLICLE-STIMULATING-HORMONE IN POLYCYSTIC-OVARY-SYNDROME

This case report describes the first established pregnancy and birth a fter induction of ovulation with recombinant human follicle-stimulatin g hormone (FSH) in a woman suffering from chronic clomiphene-resistant anovulation due to polycystic ovary syndrome (elevated serum luteiniz ing hormone and testosterone concentrations together with polycystic o varies). Starting on day 3 of a progestagen withdrawal bleeding, 75 IU of rFSH was administered i.m. daily until a single preovulatory folli cle was seen upon transvaginal ultrasound examination at day 13. Ovula tion was induced by a single i.m. administration of 10 000 IU of human chorionic gonadotrophin, after which a viable singleton pregnancy was revealed at a gestational age of 6 weeks. The course of pregnancy and labour was uneventful and no abnormalities were found upon a paediatr ic examination.