INTRAVASCULAR LEIOMYOMATOSIS WITH UTERINE LIPOLEIOMYOMA

A very rare case of uterine lipoleiomyomata with intravascular leiomyo ma in a 48-year-old woman is described. Located in the corpus of the u terus, the lipoleiomyomata showed proliferation of leiomyocytes interm ingling with mature adipocytes. Intravascular leiomyoma was present in the broad ligament. It exhibited only spindle cells, and was reactive for HHF35 actin, without adipocytes. No continuity was detected betwe en these tumors. Immunohistochemical studies revealed that the same po rtion of the intravascular leiomyoma was positive for S-100alpha prote in, NSE, factor VIII-related antigen, and HHF35 actin. These findings suggest that the leiomyomatous tumor components arise from multipotent undifferentiated mesenchymal stem cells. (C) 1994 Academic Press, Inc .