Mx. Ransom et al., DOES INCREASING FREQUENCY OF INTRAUTERINE INSEMINATION IMPROVE PREGNANCY RATES SIGNIFICANTLY DURING SUPEROVULATION CYCLES, Fertility and sterility, 61(2), 1994, pp. 303-307
Objective: To compare pregnancy rates (PR) per treatment cycle of cont
rolled ovarian hyperstimulation (COH) patients receiving a single IUI
with COH patients receiving two IUIs. Design: A prospective randomized
trial of consecutively treated patients attending our infertility cli
nic for COH and IUI. Methods: Patients undergoing COH by hMG and hCG w
ere randomized to receive either one (group A) or two (group B) IUIs.
Randomization was performed using a random number table. Group A IUIs
were timed 35 hours after ovulatory hCG, whereas group B IUIs were per
formed 19 and 43 hours after hCG. Results: A total of 120 patients dur
ing 169 cycles were randomized between group A (90 cycles) and group B
(79 cycles). Data analysis demonstrated no significant differences be
tween groups A and B with respect to age, indications for COH, duratio
n of hMC treatment, total amount of hMG administered, peak E(2) levels
, number of dominant follicles recruited, or mean number of total moti
le sperm inseminated. Pregnancy rates for groups A and B were 0.11 and
0.14, respectively. The size of our study population permits a conclu
sion that a 300%, 200%, or 100% difference in PR between the two group
s does not exist (power 0.97, 0.80, or 0.61, respectively). Conclusion
: Among patients undergoing COH and IUI, increasing the frequency of i
nsemination does not provide a significant increase in cycle pregnancy
rate.