SYNTHESES OF 2,4-DIAMINOPYRIMIDINES AND 1-AMINOISOQUINOLINES IN THE REACTIONS OF ALKYL AND BENZYL KETONES WITH CYANAMIDE AND N,N-DIMETHYLCYANAMIDE

Authors
ZIELINSKI W MAZIK M
Citation
W. Zielinski et M. Mazik, SYNTHESES OF 2,4-DIAMINOPYRIMIDINES AND 1-AMINOISOQUINOLINES IN THE REACTIONS OF ALKYL AND BENZYL KETONES WITH CYANAMIDE AND N,N-DIMETHYLCYANAMIDE, Heterocycles, 38(2), 1994, pp. 375-382
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
38
Issue
2
Year of publication
1994
Pages
375 - 382
Database
ISI
SICI code
0385-5414(1994)38:2<375:SO2A1I>2.0.ZU;2-J
Abstract
The reaction of alkyl and benzyl ketones with cyanamide and N,N-dimeth ylcyanamide in the presence of POCl3 was examined. At the first stage, chloroformamidine derivatives were formed. In the presence of TiCl4, they underwent further reactions to the derivatives of 1-aminoisoquino line and 2,4-diaminopyrimidine. The effect of a constitution of substr ates on adequate ratios of heterocyclic compounds is discussed.