ADULT T-CELL LEUKEMIA-LYMPHOMA FEATURING A LARGE GRANULAR LYMPHOCYTE LEUKEMIA MORPHOLOGICALLY

A 70-year-old man from an endemic area of human T-cell lymphotropic vi rus type I(HTLV-I) developed rapid generalized lymphadenopathy and abd ominal tumours. The white blood cell count was 198.3 x 10(9)/1 with 93 % lymphocytes, 66.3% of which expressed large granular lymphocytes (LG Ls). Bone marrow and lymph nodes were also infiltrated by LGLs. Surfac e markers were positive for CD4, CD25 and HLA-DR, and negative for CD3 , CD8, CD16, CD56 and CD57. A monoclonal integration of HTLV-I provira l DNA was demonstrated on these LGLs by Southern blot hybridization an alysis. This fact indicates that some adult T-cell leukaemia/lymphoma may morphologically present LGL leukaemia.