CLINICAL AND HEMATOLOGICAL IMPROVEMENT INDUCED BY ETIDRONATE IN A PATIENT WITH IDIOPATHIC MYELOFIBROSIS AND OSTEOSCLEROSIS

We report a patient with agnogenic myeloid metaplasia associated with debilitating bone pain due to increased bone turnover and osteoscleros is. Treatment with etidronate at a dose of 6 mg/kg per day on alternat e months resulted in a complete recovery of bone symptoms and normaliz ation of metabolic parameters of bone turnover; unexpectedly, a sustai ned haematological improvement was also observed after several months of therapy, suggesting that bone marrow microenvironment improvement w as able to restore a nearly normal haemopoiesis. We suggest that dipho sphonate therapy may be of value in patients with AMM and increased bo ne turnover.