IMPAIRMENT OF MEMORY FOLLOWING DISCRETE THALAMIC INFARCTION

This paper presents a case of discrete thalamic infarction which damag ed various structures in the region of the left thalamus. Localisation of the lesion was confirmed by MRI scanning. From the localisation of the lesion it was concluded that damage had been inflicted on the hip pocampal pathway, the amygdalar pathway, and the pathway from perirhin al cortex to the dorso-medial thalamic nucleus. Neuropsychological eva luation revealed a severe verbal memory deficit on anterograde tests c omparable with that shown by alcoholic Wernicke-Korsakoff patients. In contrast performance on non-verbal memory measures was normal. Perfor mance on retrograde amnesia tests indicated near-normal performance. A final finding was that memory for temporal information was impaired f or both verbal and non-verbal information but only an anterograde test s. The data provide support for the view that a lesion in the anterior thalamus can produce amnesia if it compromises the hippocampal pathwa y and either the amygdalar pathway or that arising from the perirhinal cortex and terminating in the dorso-medial nucleus of the thalamus. O n the basis of evidence From other studies it is concluded that the mo st likely interpretation is that the lesion must compromise the hippoc ampal and perirhinal cortex pathways. The pattern of memory impairment is described in some detail and these provide a basis for discussing the role of diencephalic structures in memory performance.