EFFECT OF DRUG-METABOLIZING ENZYME-ACTIVITY INDUCED BY PCB ON THE DURATION OF DRUGS IN FISH

A study was made of the induction of drug-metabolizing enzyme activity and the effect of the induced activity on the duration of drugs in fi sh. Carp were fed with a diet containing PCB (0.1 mg PCB/100 g body we ight day-1) for 2 weeks to induce drug-metabolizing enzymes. After pre treatment, oxolinic acid, thiamphenicol and oxytetracycline were admin istered in feed to PCB-treated and nontreated (as control) fish as a s ingle dose of 20, 50, and 50 mg/kg body weight, respectively. The peak concentrations of oxolinic acid in the blood, kidney, liver, and musc le of fish in the PCB group were lower than the half of those in the c ontrols. Furthermore, the duration times of oxolinic acid in the tissu es of PCB-treated fish were also shorter than those in the control. Ho wever, the duration of thiamphenicol and oxytetracycline showed no sig nificant changes relating to PCB treatment.