A massive, locally extensive adenocarcinoma of the prostate (2,246 ccm
) presenting as constipation and a palpable abdominal mass, was treate
d with androgen deprivation resulting in a 94 percent reduction in tum
or size, and relief of symptoms. Serum prostate-specific antigen was r
educed from 4,029 to 0.4 ng/mL, after hormonal therapy was combined wi
th radiation treatments for local disease control.