ROLE OF ENVIRONMENT AND GENETIC-FACTORS I N URINARY CALCIUM STONE DISEASE

In this prospective study, we compared the frequency of some genetic a nd environmental factors possibly implicated in the occurrence of calc ium stone disease. A group of 439 patients (258 males and 181 females) with one episode of calcium stone was compared to a group of 191 pati ents (131 males and 60 females) with recurrent calcium stone disease. Population with stones was also compared to control population (n=78, 40 males and 38 females) matched to age. Major results were as follow: 1) Family history of urinary calculi was more frequent in patients th an in controls (28.4% vs 9%, p < 0.01). No difference was observed bet ween patients with one episode and those with recurrent episodes (27% vs 31 %, ns). 2) The recurrence was earlier in female than in male, so that in female with family history of urinary calculi (p < 0.05). 3) Mean plasma levels of 1-25OH2D3 was significantly higher in patients w ith family history than in controls (60% vs 38%, p < 0.01) 5) Restrict ed calcium diet (< 400 mg per day) was more often observed in patients than in controls (31 % vs 14%, p < 0.05) and the most significant dif ference was found in patients with recurrent calcium stones.