Background: Some patients with pathological jealousy have a predominan
t obsessional component to their jealous thoughts. Since obsessions an
d compulsions often respond to serotonin reuptake blockers, these agen
ts may also be useful for obsessional jealousy. Method: We undertook a
retrospective study of patients who presented with obsessional jealou
sy. Six patients were treated in open clinical practice with serotonin
reuptake blockers. Results: Four of the six patients responded to med
ication. This response was as robust as that seen in patients with cla
ssical symptoms of obsessive compulsive disorder. Conclusion: Obsessio
nal jealousy has phenomenological similarities to other obsessions and
compulsions, and obsessional jealousy may also respond to standard an
tiobsessional medications.