BIOGENESIS OF SYNAPTIC VESICLES

Authors
KELLY RB BONZELIUS F CLEVES A CLIFTOGRADY L GROTE E HERMAN G
Citation
Rb. Kelly et al., BIOGENESIS OF SYNAPTIC VESICLES, Journal of Cell Science, 1993, pp. 81-83
Citations number
8
Categorie Soggetti
Cytology & Histology
Journal title
Journal of Cell Science → ACNP
ISSN journal
00219533
Year of publication
1993
Supplement
17
Pages
81 - 83
Database
ISI
SICI code
0021-9533(1993):<81:BOSV>2.0.ZU;2-Z
Abstract
The basic endosomal recycling pathway can be modified to generate tran scytotic vesicles, storage vesicles and synaptic vesicles. Sorting int o synaptic vesicles requires specialized sorting information not prese nt in the transcytotic and storage vesicle proteins. Using mutagenesis we have distinguished the signals for rapid endocytosis and SV target ing in synaptobrevin. Finally, we have evidence that synaptic vesicles can be generated from an endosomal compartment in vitro.