Growth hormone-releasing hormone (GHRH) is limited as a diagnostic too
l in both growth hormone (GH) deficiency and acromegaly. Measurement o
f a GHRH level may be helpful in patients with acromegaly suspected to
have ectopic production of this peptide. The greatest potential of GH
RH lies in its ability to be used as a therapeutic agent, either in GH
deficient states or, possibly, as an antagonist in acromegaly. Either
a long acting preparation or a preparation formulated to be active or
ally would greatly potentiate the clinical application of this peptide
.