IMIPRAMINE ANTAGONISM OF THE PANICOGENIC EFFECTS OF CHOLECYSTOKININ TETRAPEPTIDE IN PANIC DISORDER PATIENTS

Authors
BRADWEJN J KOSZYCKI D
Citation
J. Bradwejn et D. Koszycki, IMIPRAMINE ANTAGONISM OF THE PANICOGENIC EFFECTS OF CHOLECYSTOKININ TETRAPEPTIDE IN PANIC DISORDER PATIENTS, The American journal of psychiatry, 151(2), 1994, pp. 261-263
Citations number
11
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
The American journal of psychiatry → ACNP
ISSN journal
0002953X
Volume
151
Issue
2
Year of publication
1994
Pages
261 - 263
Database
ISI
SICI code
0002-953X(1994)151:2<261:IAOTPE>2.0.ZU;2-0
Abstract
Eleven panic disorder patients who panicked in response to exogenous c holecystokinin tetrapeptide (CCK-4) were rechallenged after chronic tr eatment with imipramine. In the rechallenge the patients displayed a m arked reduction in the number and intensity of panic symptoms, duratio n of symptoms, frequency of panic attacks, and cardiovascular responsi veness. This study demonstrates that imipramine can antagonize the pan icogenic effects of CCK-4.