From 1983 to 1992, nine above-knee amputations were performed in eight
patients for complications after total knee arthroplasty. The mean ti
me from the initial knee replacement to amputation was 9.7 years. The
average age of the four men and four women was 72 years. Eight knees h
ad chronic infection and one had intractable pain after four revision
attempts for aseptic loosening. Most patients had two revision arthrop
lasties after the original implant. In this series, the common factors
that lead to amputation were multiple revision attempts in the presen
ce of chronic infection, severe bone loss, and intractable pain. Earli
er consideration of arthrodesis rather than multiple revision attempts
is recommended to avoid such a poor outcome.