SUBPOPULATIONS OF PERIPHERAL-BLOOD NEUTRO PHILS AND LYMPHOCYTES IN CHILDREN WITH IMMUNE NEUTROPENIA

Peripheral blood (PB) neutrophils and lymphocytes from 14 patients wit h immune neutropenia were studied using the technique of rosette-forma tion in 2 neutrophil fractions with diverse specific density. All the neutropenia cases were divided into 2 groups by phagocytosis completen ess in all the PB neutrophil types studied. Patients of group 1 had im paired phagocytosis D-RFN in elevated levels of these cells, autoroset te forming lymphocytes and neutrophils. Patients of group 2 had defect ive phagocytoses D-RFN and EAC-RFN in combination with extremely high contents or autorosette-forming including early lymphocytes. The above complex of techniques may be used for prediction of the duration and severity of neutropenia which is important for further selective studi es into the causes of neutropenia and effective treatment.