THE TREND IN RED-CELL METABOLISM IN SEVER E MENINGOCOCCAL INFECTION AND PURULENT-MENINGITIS IN CHILDREN

In 63 children with severe meningococcal infection (MI) and meningitid es of another origin red cell metabolism was studied: levels of ATP, A DP, AMP, ATP/ADP, ATP/AMP, energetic charge, 2,3-DPG, FAD, piruvate, l actate, activity of lactate dehydrogenase, piruvate kinase, glucose-6- phosphate dehydrogenase, glutatione reductase, Mg2+, Na+ K+-dependent ATPase. All the disease periods were characterized by combined pathobi ochemical shifts of different degree typical for varying metabolic sys tems and correlating with the infection severity. The discussion cover s pathogenetic and clinical significance of red cell metabolise shifts in patients with MI and purulent meningitides.