APPLICATION OF A NEW METHOD OF MEASURING THE RATIO GLOMERULAR-FILTRATION RATE TO PLASMA-VOLUME IN HYPERTENSIVE PATIENTS

Renal scintigrams with Tc-99-DTPA were analysed retrospectively in 19 patients with essential hypertension. Glomerular filtration rate (GFR) was measured by Gates technique. Ratio GFR to plasma volume (PV) was quantified by A. M. Peters' technique (1994). PV was calculated as the relation of these two indices. Total GFR in hypertensive patients wid ely ranged (from 76.8 ml/min to 165.7 ml/min). Three groups were selec ted taking into account hypertension duration: patients with decreased , normal and increased values of basal GFR. The severity of hypertensi on did not affect the GFR, but showed positive and strong correlation with PV (r=0.91; p<0.05). GFR/PV was decreased in hypertensive patient s. Factors affecting the GFR in hypertensive subjects are discussed.