ARAGUSTEROL-C - A NOVEL HALOGENATED MARINE STEROID FROM AN OKINAWAN SPONGE, XESTOSPONGIA SP, POSSESSING POTENT ANTITUMOR-ACTIVITY

Authors
SHIMURA H IGUCHI K YAMADA Y NAKAIKE S YAMAGISHI T MATSUMOTO K YOKOO C
Citation
H. Shimura et al., ARAGUSTEROL-C - A NOVEL HALOGENATED MARINE STEROID FROM AN OKINAWAN SPONGE, XESTOSPONGIA SP, POSSESSING POTENT ANTITUMOR-ACTIVITY, Experientia, 50(2), 1994, pp. 134-136
Citations number
4
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Experientia → ACNP
ISSN journal
00144754
Volume
50
Issue
2
Year of publication
1994
Pages
134 - 136
Database
ISI
SICI code
0014-4754(1994)50:2<134:A-ANHM>2.0.ZU;2-O
Abstract
A novel chlorinated steroid, aragusterol C, was isolated from an Okina wan marine sponge of the genus Xestospongia. The compound strongly inh ibited the proliferation of KB cells in vitro, and also showed potent in vivo antitumor activity against L1210 cells in mice. The complete s tructure of aragusterol C was determined by spectroscopic analysis and X-ray crystallographic analysis.