SYNTHESIS OF NEW 5-AMINOOROTIC ACID-DERIVATIVES AS ANTIMICROBIAL AGENTS

Reaction between 5-Aminoorotic acid and alkyl or aryl halides in dimet hylformamide gave esters and/or 1-alkyl substituted orotates depending upon experimental conditions. These compounds were converted into the corresponding 5-acylamino derivatives. The later derivatives were tes ted in vitro against gram+ and gram- bacteria. The great majority of t hem show significant growth inhibitory effects. Moreover, some others are specific inhibitors for gram+ bacteria.