HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF CYCLOSPORINE-A AND ITS ORAL SOLUTIONS

Authors
HUSEK A
Citation
A. Husek, HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF CYCLOSPORINE-A AND ITS ORAL SOLUTIONS, Journal of chromatography, 759(1-2), 1997, pp. 217-224
Citations number
18
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of chromatography → ACNP
Volume
759
Issue
1-2
Year of publication
1997
Pages
217 - 224
Database
ISI
SICI code
Abstract
Different columns and conditions were evaluated for the HPLC analysis of cyclosporin A, its congeners and degradation products. The optimise d conditions were compared with the pharmacopoeial HPLC method for cyc losporin A analysis and some modifications, applicable among others fo r the stability studies of oral dosage forms, are proposed.