G. Joseph et al., A COMPARISON OF HEMOSTATIC PARAMETERS IN HYPOTHERMIC VERSUS NORMOTHERMIC CARDIOPULMONARY BYPASS, Journal of interventional cardiology, 7(1), 1994, pp. 7-16
Ten patients who underwent PCPS (group A) at our institution were eval
uated for hemostatic abnormalities and compared to an age matched popu
lation undergoing open CPB (group B) to study the effects of CPB indep
endent of the effects of hypothermia. Both groups had hemostatic param
eters measured prior to, 1 hour after, and 16-24 hours following compl
etion of the procedure. The mean duration of perfusion for group A was
53.7 +/- 13.5 minutes and group B 108.1 +/- 26.5 minutes (P < 0.0001)
. There were no significant differences in hemoglobin, platelet count,
congulation factors, and rests of in vitro platelet function between
groups A and B at the different rime points. While bleeding times for
group B returned to baseline within an hour following bypass, they rem
ained significantly prolonged in group A 24 hours later (P = 0.02). Co
nclusion: Normothermic bypass used during PCPS results in platelet fun
ction abnormalities similar to open hypothermic CPB suggesting the dom
inant role of the membrane oxygenator over hypothermia in inducing the
platelet dysfunction.