EFFECTS OF NAFTOPIDIL ON SOME URODYNAMIC PARAMETERS AND ARTERIAL BLOOD-PRESSURE IN COMPARISON WITH PRAZOSIN IN CONSCIOUS RATS

Naftopidil, an alpha(1)-adrenergic antagonist, was orally tested in co mparison with prazosin, in a rat cystomanometric model to evaluate the effect on the bladder volume capacity (BVC), the micturition pressure (MP) and the mean arterial blood pressure (MAP), contemporaneously re corded to evaluate the selectivity of action. Naftopidil induced a cle arcut increase of BVC and a decrease of MP without lowering MAP at 6.2 5 mg kg(-1) p.o.. Prazosin was inactive on BVC, decreased MP and induc ed a significant decrease of MAP at 1.56 mg kg(-1) p.o. Naftopidil cou ld offer an advantage when compared with prazosin. (C) 1996 The Italia n Pharmacological Society.