D. Palomba et al., METABOLIC AND RENAL EFFECTS OF LAEVO-CARNITINE AND PROPIONYL-CARNITINE IN RATS WITH SUBTOTAL NEPHRECTOMY, Pharmacological research, 34(3-4), 1996, pp. 161-165
The renal and metabolic effects of chronic carnitine administration we
re evaluated in the early stages of experimentally-induced renal failu
re. Laevo-carnitine (n=5), Propionyl-carnitine (n=5) both at 200 mg kg
(-1) of body weight, or Vehicle (physiological saline solution, 0.4 ml
kg(-1) body weight, n=5) were administered daily for 3 days prior to
2/3 nephrectomy and for 25 days thereafter, by intraperitoneal route.
At the end of the experiment, no significant differences were found in
systolic blood pressure and heart rate among groups. During the 25 da
ys after nephrectomy, body weight increased by 71+/-13 g in the contro
l group and by 50+/-26 g and 42+/-9 g in Laevo-carnitine and Propionyl
-carnitine groups, respectively (P<0.05 vs control for both comparison
s) Urinary sodium excretion was increased in carnitine-treated rats (L
aevo-carnitine: from 1.03+/-0.3 to 1.36+/-0.3 mEq day(-1), Propionyl-c
arnitine: from 1.2+/-0.2 to 1.66+/-0.2 mEq day(-1), P<0.05 for both co
mparisons), but not in those given vehicle. Twenty-five days after nep
hrectomy, plasma creatinine was lower in carnitine-treated rats (Laevo
-carnitine: 0.98 +/- 0.12 mg dl(-1), Propionyl-carnitine: 1.06+/-0.15,
vehicle: 1.52+/-0.09, P<0.05 vs control for both comparisons). Plasma
triglycerides and VLDL were decreased by nephrectomy and this effect
was prevented by carnitine treatment. The data indicate that the carni
tine blunts the increase in plasma creatinine that occurs early after
partial nephrectomy and normalizes the plasma lipoprotein pattern. Thu
s, carnitine might protect against the development of renal failure in
this experimental model. (C) 1996 The Italian Pharmacological Society
.