C. Gianoulakis et al., INCREASED PLASMA ATRIAL-NATRIURETIC-PEPTIDE AFTER INGESTION OF LOW-DOSES OF ETHANOL IN HUMANS, Alcoholism, clinical and experimental research, 21(1), 1997, pp. 162-170
Previous studies have demonstrated that, in human, acute consumption o
f high doses of ethanol, administered in a large quantity of fluid, wi
th or without volume-loading, induced either a decrease or an increase
In the plasma content of atrial natriuretic peptide (ANP)-a substance
that has a hypotensive effect. The objective of the present study was
to examine the effect of low doses of ethanol (0, 0.25, and 0.50 g of
ethanol/kg of body weight) administered to six normotensive individua
ls, in a small volume of fluid without prior volume-loading. Before an
d at various intervals after administration of the placebo or ethanol
drinks, heart rate and brood pressure were measured and blood samples
were taken for estimation of the plasma ANP, arginine vasopressin, and
cortisol contents. Results indicated small changes in blood pressure
and heart rate after ingestion of either the placebo or ethanol drinks
. On the other hand, a significant increase in the plasma ANP content
was observed at 15 min after ingestion of both the 0.25 and 0.50 g of
ethanol/kg of body weight doses, but not after the placebo drink. Plas
ma ANP levels were still elevated at 45 min postethanol intake, but ha
d returned to basal levels at 120 min after the ethanol drink. Interes
tingly, it was noticed that the higher dose of ethanol (0.50 g) did no
t induce a higher plasma ANP concentration than the lower dose (0.25 g
) of ethanol; however, the plasma ANP content remained elevated for a
longer period. Furthermore, the increase in plasma ANP content was not
due to ethanol or stress-induced increases in the plasma arginine vas
opressin and cortisol contents, because the plasma concentration of th
ese hormones remained either at basal or below basal levels for the du
ration of the experiment. In conclusion, ingestion of low amounts of e
thanol equivalent to 1 or 2 standard drinks induced an increase in pla
sma ANP content.