The development of severe tardive dystonia after short-term use of low
-dose Fluspirilen is described. A 39-year-old woman was treated with F
luspirilen IM by her family doctor for reactive depression. She did re
ceived no other neuroleptic agents and no risk factors for the develop
ment of tardive dyskinesia (e. g. old age or organic brain damage) wer
e present. For the first time a relation between short-term monotherap
y with Fluspirilen and tardive dyskinesia appears highly probable. The
use of Fluspirilen for the treatment of psychogenic disturbances shou
ld therefore be considered carefully.