LACK OF ASSOCIATION BETWEEN ALPHA-1-ANTICHYMOTRYPSIN POLYMORPHISM, ALZHEIMERS-DISEASE, AND ALLELE EPSILON-4 OF APOLIPOPROTEIN-E

Authors
MULLER U BODEKER RH GERUNDT I KURZ A
Citation
U. Muller et al., LACK OF ASSOCIATION BETWEEN ALPHA-1-ANTICHYMOTRYPSIN POLYMORPHISM, ALZHEIMERS-DISEASE, AND ALLELE EPSILON-4 OF APOLIPOPROTEIN-E, Neurology, 47(6), 1996, pp. 1575-1577
Citations number
15
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
47
Issue
6
Year of publication
1996
Pages
1575 - 1577
Database
ISI
SICI code
0028-3878(1996)47:6<1575:LOABAP>2.0.ZU;2-I
Abstract
We investigated the possibility that a polymorphism of alpha 1-antichy motrypsin modifies the risk for Alzheimer's disease (AD). Testing 147 AD patients and 74 controls, we did not find evidence of an associatio n between alpha 1-antichymotrypsin polymorphism and AD and also failed to detect a modifying effect of this polymorphism in patients carryin g at least one epsilon 4 allele of apolipoprotein E.