ENZYME ELECTROPHORESIS, SEROTYPING AND SUBTYPING, AND OUTER-MEMBRANE PROTEIN CHARACTERIZATION OF 2 NEISSERIA-MENINGITIDIS STRAINS INVOLVED IN LABORATORY-ACQUIRED INFECTIONS
M. Guibourdenche et al., ENZYME ELECTROPHORESIS, SEROTYPING AND SUBTYPING, AND OUTER-MEMBRANE PROTEIN CHARACTERIZATION OF 2 NEISSERIA-MENINGITIDIS STRAINS INVOLVED IN LABORATORY-ACQUIRED INFECTIONS, Journal of clinical microbiology, 32(3), 1994, pp. 701-704
Two cases of laboratory-acquired infections due to Neisseria meningiti
dis were Suspected to have occurred in two French hospitals. The first
case occurred shortly, i.e., 3 days, after one strain had been handle
d by a laboratory technician, and the link between this strain and the
strain causing meningitis was easily established. In the second case,
infection occurred 3 weeks after 10 strains had been handled by a tec
hnician. In this case, it was necessary to use high-resolution markers
in order to establish the link between the infecting strain and I of
the 10 strains handled. The antigenic formulae of the two infecting st
rains (serogroup: serotype:subtype) were, respectively, C:NT:P1.12 and
B:2a:P1.2. Outer membrane protein profile analysis and multilocus enz
yme electrophoresis unequivocally confirmed the identity of the respec
tive strains.